The objective of this work is the preparation of nanocapsules which are intended for the treatment of rheumatoid arthritis (RA).\nWe use Argan oil as vehicle of hydrophobic drugs such as indomethacin. Nanoprecipitation technique was used like a method for\npreparation of nanocapsules, where polycaprolactone, acetone, and Argan oil are used as polymer, solvent, and carrier, respectively.\nPrimarily, investigation of Argan oil amount addition was performed; then systematic study to optimize the formulation was\ndone. Nanocapsules containing indomethacin (loaded nanocapsules) and others without indomethacin (blank nanocapsules) were\ncharacterized by studying particles size, zeta potential, and encapsulation efficiency. It is shown that particle size ranged between\n290 nmand 350 nm.Thezeta potential valueswere negative (from?40 up to ?50mV)while encapsulation efficiency ranged between\n65 and 75%.
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